The 10 year survival rate is about 80100% the prognosis of the condition is typically excellent, when the carcinoma is in its pure state not exhibiting mixed pattern of other tumor types. This procedure involves the removal of the carcinoma tissues and a layer of surrounding healthy tissue to avoid the chance of recurrence of mucinous carcinoma. Mucinous breast carcinoma is an uncommon form of breast cancer that has a good prognosis compared to the common invasive ductal carcinoma it is also known as mucinous carcinoma of the breast, and colloid carcinoma of the breast. Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type. Those carcinomas in which this is a predominant feature comprise less than 2% of all cases of breast carcinoma, and may have neuroendocrine features. Invasive pleomorphictype lobular carcinoma of the breast. Mucinous carcinoma is less likely to spread to the lymph nodes than other types of breast cancer.
Mucinous breast cancer, also called colloid breast cancer, is a rare kind of invasive ductal breast cancer. Mucinous carcinoma of the breast breast cancer mystory. Mucinous carcinoma is a unique histologic subtype of breast cancer with a good prognosis. Anderson cancer center found that, in a sample of more than 260 women with mucinous carcinoma, about 38% had more than one area of cancer within the breast. It recurs late, metastasis to axillary lymph nodes is less. Mucinous carcinoma of the breast in comparison with invasive. If you go to and do a search for mucinous or colloid carcinoma, you will find discussions about it. Typically, mucinous carcinoma expresses estrogen and progesterone receptors and lack of her2 amplification. Mucinous carcinoma an overview sciencedirect topics. Mc of the breast is defined as having a mucinous component of 50% or more. Like other types of invasive ductal cancer, mucinous breast cancer begins in the milk duct of the breast. Invasive mucinous carcinoma of the breast is mostly associated with invasive carcinoma of no special type nst and sometimes with neuroendocrine type tumors such as solid papillary carcinoma. A 58yearold woman underwent mastectomy of the right breast. The patient underwent neoadjuvant chemotherapy without any response.
Even though mucinous carcinoma is an invasive breast cancer, it tends to be a less aggressive type that responds well to treatment. It is a disease of older women, it has been described that only 1% of patients with mucinous carcinoma of the breast are younger than 35 years 2. A large study carried by busam and coworkers evaluated the staining pattern of primary cutaneous sweat gland carcinoma and primary or metastatic breast carcinoma. Three patterns of mucinous carcinoma have been described. Microlobulated and circumscribed margins were commonly found in mucinous carcinoma 1833, 54. Mucinous breast cancer is a type of invasive breast cancer. Pure mucinous carcinoma of the breast surgical pathology. The original description of chc was that of an intraductal carcinoma. They account for about 2% range 17% 4 of breast cancers. In this study we have analysed fine needle aspiration fna cytological material from 28 cases of mc of breast and correlated the cytomorphological features with histopathology.
Mucinous carcinoma is a variant of invasive breast carcinomas that accounts for 2% of them and has a better prognosis in contrast to the nonspecific invasive carcinoma. Mucinous carcinoma mc of the breast is a rare histological type that is characterized by a large amount of mucin production. Detached epithelial elements present floating in the mucin. Mucinous carcinoma of the breast is one of the most common special histological types of breast carcinoma, but locally aggressive growth to form a large skin ulcer is rarely. Pdf her2 positive mucinous carcinoma breast cancer, case. Pure mucinous carcinoma mc of the breast is a relatively uncommon variant of breast carcinoma with distinctive histological and cytological features.
Jan 21, 2020 some recent research has suggested that, in cases of mucinous carcinoma, a certain percentage of women will have more than one mucinous tumor in the breast. Mucinous carcinomas of the breast constitute only 14% of primary breast carcinomas. Mucinous carcinoma of the breast, also known as colloid breast carcinoma, is a subtype of invasive ductal carcinoma idc. Mucinous carcinoma of the breast is an uncommon form of breast tumor, often presenting as a lobulated, moderately well circumscribed mass on mammography, sonography, and mri imaging. Primary cutaneous mucinous carcinoma pcmc is a rare lowgrade malignant neoplasm originally believed to be of eccrine origin. Some recent research has suggested that, in cases of mucinous carcinoma, a certain percentage of women will have more than one mucinous tumor in the breast. In case of the mucinous carcinoma of the breast, lumpectomy is the best procedure to cure the disease. Mucinous carcinoma of the breast occurs preferentially in older women and is associated with good clinical outcome 14. The incidence of mc was reported to be 16% of all primary breast. The survival rate for pure mucinous carcinoma of the breast is better than most other types of invasive breast cancer. The patient did not seek any medical attention for two years. Mucinous carcinoma of the breast radiology reference. Pdf mucinous carcinoma of the breast is genomically. Pathologic spectrum of secretory and mucinous breast lesions.
Recent molecular studies reveal distinct genomic changes in mucinous carcinoma. Apr 09, 2020 mucinous colloid carcinoma is another rare histologic type, seen in fewer than 5% of invasive breast cancer cases. Research suggests that only about 23% of invasive breast cancers are pure mucinous carcinomas meaning that this is the only type of cancer. Represents 17 % of total breast cancers and typically has a prevalence of 7% in women. Mucinous carcinoma of the breast accompanied by coarse. Mucinous carcinoma of the breast is one of the rarer forms of intramammary cancer, often presenting as a lobulated, fairly well circumscribed mass on mammography, sonography, and gadoliniumenhanced magnetic resonance imaging. Case report primary mucinous cystadenocarcinoma of the.
It usually presents during the seventh decade of life as a palpable mass or. Mucinous carcinoma of breast is a type of invasive breast cancer that normally has an excellent outcome. Locally advanced mucinous carcinoma of the breast with sudden. The national comprehensive cancer networkref3 recommends using the nottingham criteriaref4 in grading invasive carcinoma of the breast. Also called colloid carcinoma, it develops more often in women aged 60 to 70 years. J med ultrasound 2005 vol no 118 mucinous carcinoma of the breast. This means it has the potential to spread from the breast to other parts of the body. Mucinous carcinoma of the breast is a rare entity with a favorable prognosis due to low incidence of lymph node metastases. Mucinous carcinoma of the breast sometimes called colloid carcinoma is a rare form of invasive ductal carcinoma cancer that begins in the milk duct and spreads beyond it into nearby healthy tissue. I was diagnosed last february with pure mucinous breast cancer. On mammography, the appearance of pure and mixed mucinous carcinoma is different. In this type of cancer, the tumor is made up of abnormal cells that float in pools of mucin. Extracellular mucin production in invasive lobular carcinoma.
Mucinous carcinoma, especially in males and older females, can arise in association with solid papillary carcinoma. It is also known as mucinous carcinoma of the breast, and colloid carcinoma of the breast. Pure mucinous carcinoma of the breast stanford university. Mucinous carcinoma of the breast is a rare histological type of breast cancer and differs both by its molecular characteristics as clinical epidemiological among these. Misdiagnosis of pmcs is common, as it has an uncharacteristic gross appearance and may microscopically resemble cutaneous metastasis from a mucinous carcinoma of the breast. This result made this antibody unreliable in differentiating both entities. Histopathologically, it is classified into two forms, pure and mixed type. Misdiagnosis of pmcs is common, as it has an uncharacteristic gross appearance and may microscopically resemble cutaneous metastasis from a mucinous carcinoma of the breast, gastrointestinal tract, lungs, ovaries, or prostate. A comprehensive understanding of the varied nature a mucinous lesion is imperative to ensure consideration of appropriate interventional investigations.
Mucinous carcinoma accounts for approximately 2% of all breast cancer and is a rare subtype of infiltrating ductal carcinoma. It accounts for only 2% of total breast carcinomas. Primary mucinous carcinoma of the skin mdedge dermatology. Multifocal invasive mucinous carcinoma of the breast. Nov 27, 2018 mucinous carcinoma of breast is a type of invasive breast cancer that normally has an excellent outcome. Smaller tumors may be too little to detect with touch, but larger tumors may press on surrounding breast tissue and cause the area to feel tender. Sonographic appearance of mucinous carcinoma of the breast. Elastographic evaluation of mucinous carcinoma of the breast. Mucinous carcinoma is a rare histological special type of invasive breast cancer, accounting for up to 2% of all breast carcinomas. Established prognostic markers that are relevant for all other types of breast cancer also apply to mucinous breast cancer.
In addition to this, the presentation of multifocal mucinous carcinoma of the breast is unique. May be trabecular, cribriform, micropapillary, sheet like or clumps. In a way akin to mucinous cancers of other anatomical sites, mucinous. It usually presents during the seventh decade of life as a. The study that you refer to regarding multifocal mucinous breast cancer was done by george perkins, md at md anderson. In the context of mucinous carcinoma, the presence of mucin in a margin constitutes involvement by carcinoma. Diagnostic criteria based on ultrasonography huayben pan 1,2, tsunglung yang 1, chenpin chou 1, jershyung huang 1, hueilung liang 1, huihwa tseng 3 g background. Core needle biopsy showed invasive mucinous adenocarcinoma without ductal component. In the case of mucinous carcinoma in the breast, this lump may be felt during a selfexam or a doctors examination. Under a microscope, it looks like the cancer cells are scattered throughout pools of mucus. If you have a pure mucinous carcinoma meaning that 90100% of the tumor is made up of the characteristic cells floating in mucus, without other types of breast cancer cells mixed in it typically will require less treatment than other types of invasive ductal carcinoma idc. Most of the patients are elderly and tumors are generally considered to have a relatively good prognosis when identified as pure mucinous tumors.
Mucinous carcinoma is a rare, special subtype of breast carcinoma associated with good prognosis, it is a disease of elderly patient, over 60 years, and usually occurs in postmenopausal women. Conclusion the appearance of an invasive mucinous carcinoma of the breast can differ clinically, radiologically and pathologically. Mucinous carcinoma is a type of invasive ductal carcinoma figure 1, quite rare, accounting for only 1 to 7% of breast cancers ref. Mucinous or colloid breast carcinoma mbc is an uncommon subtype of invasive ductal carcinoma idc, representing between 1% and 7% of all breast.
Mucinous carcinoma of the breast colloid or adenocarcinoma is the main type of well differentiated infiltrating ductal carcinoma. Mri features of pure and mixed forms with histopathologic correlation shuichi monzawa 1 2, masaki yokokawa 1 3, toshiko sakuma 4, shintaro takao 5. A gelatinous tumor of mucinous carcinoma of the breast will feel like a slightly bumpy water balloon, similar to harmless fluidfilled cysts. Mucinous lesions of the breast include a variety of benign and malignant epithelial processes that display intracytoplasmic or extracellular mucin, including mucocelelike lesions, mucinous. The incidence of mc was reported to be 16% of all primary breast cancers 18. A large study carried by busam and coworkers evaluated the staining pattern of primary cutaneous sweat gland carcinoma and primary or metastatic breast carcinoma 4. A breast carcinoma of which at least one half of the volume of the tumor is extracellular mucin throughout. Gross histology of mucinous carcinoma usually shows round tumors with circumscribed margins, which has good correlation with the mammographic appearance as shown in our study and the study of matsuda et al. The typing of invasive breast carcinoma and its histological variants is well established. Mucinous carcinoma can also be detected as a lump during a mammogram or mri. Breast cancer is the most common malignant tumor in women. In previous studies, the benign imaging features of mucinous carcinoma mca of the breast.
In mucinous carcinoma, however, mucin becomes part of the tumor and surrounds the breast cancer cells. Mucinous carcinoma is a slowgrowing neoplasm, and late systemic metastases have been reported. Mucinous carcinoma of the breast in comparison with. Mucinous breast cancer, also called colloid breast cancer, is a rare type of invasive ductal breast cancer that accounts for less than 2% of all breast cancers. We report a case of giant mucinous carcinoma of the breast in a 55yearold female who presented with left breast lump for two years. Mucinous carcinoma consists of tumor cell nests and clusters floating in mucin, similar to mucinous carcinoma of the breast. The brazilian radiological literature has emphazised the importance of imaging methods in the improvement of breast cancer diagnosis14. Primary mucinous carcinoma of the skin pmcs is a rare malignant adnexal tumor. Mucinous carcinoma or mucinproducing carcinoma is a type of invasive ductal breast cancer. Mucinous breast carcinoma is an uncommon form of breast cancer that has a good prognosis compared to the common invasive ductal carcinoma. Like other types of invasive ductal cancer, it starts in a milk duct of the breast and spreads to nearby healthy tissues. Its sometimes found alongside another type of breast cancer called invasive ductal breast cancer. Jan 23, 2020 the proliferative nature of a mucinous carcinoma is reported to be slow and non.
Histologically, it is an invasive epithelial tumor. Its characterized by cell mucin production in varying amounts, which are detected in the tumor stroma. Mucinous breast carcinoma is rare subtype of breast cancer. In general, breast carcinoma is divided into ductal carcinoma. Furthermore, when mucinous carcinoma, a kind of softer breast cancer because of the abundant mucus it contains 22, is concerned, our results showed that 100% 33 of them with swvs. In one study, the fiveyear survival rate of pure mucinous carcinoma. Epidemiology it tends to occur in older women where a prev. The distinguishing feature of mucinous cancer sometimes called colloid cancer is the production of mucus.
Mucinous colloid carcinoma is another rare histologic type, seen in fewer than 5% of invasive breast cancer cases. The proliferative nature of a mucinous carcinoma is. Locally advanced mucinous carcinoma of the breast with. Mucinous micropapillary carcinoma of the breast, also described as pure mucinous carcinoma with micropapillary pattern, has recently come to attention as an unusual form of invasive breast cancer exhibiting dual mucinous and micropapillary differentiation. This tumor can be identified on mammography, ultrasound, and mri. The 10 year survival rate is about 80100% the prognosis of the condition is typically excellent, when the carcinoma. Mucinous carcinoma of the breast has histologically distinct features and constitutes 1% 3% of all breast. Mucinous carcinoma definition of mucinous carcinoma by. Mucinous cystadenocarcinoma mca is an extremely rare variant of primary breast carcinoma that bears a striking resemblance to mcas of the ovary and pancreas.
Pure mucinous carcinoma pmc of the breast has a better prognosis than does invasive ductal carcinoma not otherwise specified and is more prevalent in older patients. Symptoms and diagnosis of mucinous carcinoma of the breast. At our institute, the prevalence of mucinous carcinoma was 3. Mucinous carcinoma of the breast colloid ductal carcinoma. No areas of the usual type of invasion of stroma in the absence of mucin. Invasive mucinous carcinoma of the breast is characterized by clusters of neoplastic cells floating in extracellular mucin. The tumor, or lump, is the main symptom of mucinous carcinoma. Lesions with extravasated mucin, such as mucocelelike lesions and mucinous carcinoma, are also briefly discussed. You and your doctor will work together to develop your treatment plan for mucinous carcinoma of the breast. Pure mucinous carcinoma of the breast has low incidence of extensive intraductal spreading. Mucinous colloid breast cancer mucinous breast cancer, also called colloid breast cancer, is a rare type of invasive ductal breast cancer that accounts for less than 2% of all breast cancers. Mucinous carcinoma of the breast is one of the most common special histological types of breast carcinoma, but locally aggressive growth to form a large skin ulcer is rarely seen 1,2. It is a disease of older women, it has been described that only 1% of patients with mucinous carcinoma of the breast. Mucinous carcinoma occur in slightly older women, have a lower risk of nodal metastases, and a better prognosismost deaths occur more than 12 years after initial diagnosis.